Pengembangan Antibacterial Film dari Karboksimetil Selulosa (CMC) sebagai Solusi Ramah Lingkungan dalam Perspektif Ekonomi Islam dan SDG di Padang Lawas Utara
Abstract
The study focuses on the development of an antibacterial film derived from carboxymethyl cellulose (CMC) obtained from gebang leaves (Corypha utan), aiming to contribute to sustainable development in North Padang Lawas. The carboxymethyl cellulose was extracted from gebang leaves and utilized as a base material for film preparation. To enhance the film’s properties, carboxymethyl cellulose was combined with polyvinyl alcohol (PVA) and crosslinked with citric acid. The resulting films were evaluated for their antibacterial activity, specifically against Escherichia coli and Staphylococcus aureus. The films demonstrated significant antibacterial effects and improved water resistance with increased citric acid content. Additionally, the films exhibited a three-dimensional structure, porous network, and low toxicity, making them suitable for biomedical applications. This work underscores the potential of utilizing local plant resources for sustainable material development in North Padang Lawas, aligning with environmental and economic sustainability goals.
Penelitian ini berfokus pada pengembangan film antibakteri yang berasal dari karboksimetil selulosa (CMC) yang diperoleh dari daun gebang (Corypha utan), dengan tujuan untuk berkontribusi pada pembangunan berkelanjutan di Padang Lawas Utara. Karboksimetil selulosa diekstraksi dari daun gebang dan digunakan sebagai bahan dasar untuk pembuatan film. Untuk meningkatkan sifat film, karboksimetil selulosa dikombinasikan dengan poli(vinil alkohol) (PVA) dan dilakukan penghubungan silang dengan asam sitrat. Film yang dihasilkan dievaluasi aktivitas antibakterinya, khususnya terhadap Escherichia coli dan Staphylococcus aureus. Film menunjukkan efek antibakteri yang signifikan dan ketahanan air yang meningkat dengan penambahan asam sitrat. Selain itu, film menunjukkan struktur tiga dimensi, jaringan berpori, dan toksisitas rendah, menjadikannya cocok untuk aplikasi biomedis. Pekerjaan ini menegaskan potensi pemanfaatan sumber daya tanaman lokal untuk pengembangan material yang berkelanjutan di Padang Lawas Utara, selaras dengan tujuan keberlanjutan lingkungan dan ekonomi.
Keywords
Full Text:
PDFReferences
A.W.C. Chua, Y.C. Khoo, B. K. Tan, K.C. Tan, C.L. Foo andS.J. Chong, Burns & Traum, 4, 3 (2016), DOI:10.1186/s41038-016-0027-y
Firnanelty, S. Sugiarti and Charlena, Rasayan J. Chem., 10(2), 570(2017), DOI:10.7324/RJC.2017.1021465
S. Haberzeth-Bottcher, T. Biedermann, E. Reichmann, Burns, 36(4), 450 (2010), DOI: 10.1016/j.burns.2009.08.016.
M. Mühlstädt, C. Thomé, and C. Kunte, British Journal of Dermatology, 167, 343 (2012), DOI: 10.1111/j.1365-2133.2012.10999.x
V. Ki and C. Rotstein, Canadian Journal of Infectious Diseases and Medical Microbiology, 19, 17 (2008)
G. Nandhavathy, S. P. Selvam, M. M. Kumar and E. R. Sadiku, Rasayan J. Chem., 10(2), 542(2017), DOI: 10.7324/RJC.2017.1021724
E.Ramu, V.Kotra, N. Bansal, R.Varala and S. R. Adapa, Rasayan J. Chem., 1(1)188 (2008)
A.F. Cardona and S.E. Wilson, Clin Infect Dis, 61, S69 (2015), DOI: 10.1093/cid/civ528
M. Sand, T. Gambichler, D. Sand, M. Skrygan, P. Altmeyer, F.G. Bechara, Journal of Dermatological Sciences, 53, 169 (2009), DOI:10.1016/j.jdermsci.2008.10.004
May A.K, Surg Infect (Larchmt), 12(3), 179 (2011), DOI:10.1089/sur.2011.034
A.K. Elbadawy, X. Chen, M.S.M. Eldin, E.S. Kenawy, Arabian Journal of Chemistry, 8(1), 1(2015), DOI:10.1016/j.arabjc.2014.07.005
F.E.F. Silva, M.C.B. Di-Medeiros, K.A. Batista, and K.F. Fernandes, Journal Materials, 1(2013), DOI:10.1155/2013/413578
A.Sannino, C. Demitri, and M. Madaghiele, Materials, 2(2), 353(2009), DOI:10.3390/ma2020353
F. Jia, H.J. Liu, G.G. Zhang, Procedia Environmental Sciences, 31, 98(2016), DOI:10.1016/j.proenv.2016.02.013
A.Sannino, M. Madaghiele, F. Conversano, G. Mele, A. Maffezzoli, P.A. Netti, L. Ambrosio, L. Nicolais, Biomacromolecules, 5(1), 92 (2004), DOI:10.1021/bm0341881
D.Charpentier,G. Mocanu, A. Carpov, S. Chapelle, L. Merle and G. Muller, Carbohydrate Polymers, 32, 177 (1997), DOI:10.1016/S0144-8617(97)00031-3
D.Sahoo, S. Sahoo, J. Das, T.K. Dangar, P.L. Nayak, NanoTrends: A Journal of Nanotechnology and Its Applications, 10, 1 (2011), DOI: 10.13140/RG.2.2.10095.74406
R.E.Nasution, and H.C. Ong, In: Brink M and RP Escobin (Eds). Fibre plants. Yayasan PROSEA (Plant Resources of South East Asia) Foundation, Bogor, Indonesia, pp 114-117 (2003).
R.P.Sancayaningsih, S.H.M.B. Santosa and M.F Maharani, In Conference of International Seminar on New Paradigm and Innovation on Natural Sciences and Its Application (ISNPINSA), Semarang, Indonesia, pp 1-6 (2012).
L. Heliawati, A. Kardinan, T. Mayanti1, and R. Tjokronegoro, Journal of Applied Pharmaceutical Science, 5(1), 110 (2015), DOI: 10.7324/JAPS.2015.50119
H.B. Setiawan, H. Yudo, and S. Jokosisworo, Jurnal Teknik Perkapalan, 5(2), 1 (2017), https://ejournal3.undip.ac.id/index.php/naval/article/view/16963
R.D.Indiah, A. Yuniari, M. Sholeh, N.M. Setyadewi, In proceedings of Prosiding Seminar Nasional Kulit, Karet, dan Plastik, Yogyakarta, Indonesia, pp 1-10 (2016).
Z. Gao, Z. Yu, C. Huang, L. Duan, G.H. Gao, Journal of Applied Polyme Science, 134, 11(2016), DOI: 10.1002/APP.44590
C. M.Hassan, J. E. Stewart, and N.A. Peppas ,European Journal of Pharmaceutics and Biopharmaceutics, 49(2), 161(2000), DOI: 10.1016/S0939-6411(99)00056-9
C.Chang and L.Zhang, Carbohydrate Polymer, 84(1), 40(2011), DOI: 10.1016/j.carbpol.2010.12.023
N. Reddy and Y. Yang, Food Chemistry, 118(3), 702(2010), DOI: 10.1016/j.foodchem.2009.05.050
A. H.Saputra,M. Hapsari, A. B. Pitaloka, P. P. D. K. Wulan. In SOMCHE 2014 and RSCE 2014 Conference, Selangor Darul Ehsan, Malaysia, Journal of Engineering Science and Technology, 10, 75(2015).
M.Sauer, D. Porro, D. Mattanovich, and P. Branduard, Trends Biotechnol, 26(2), 100 (2008), DOI: 10.1016/j.tibtech.2007.11.006
E.Menzel, Olsson, T. S. Plivelic, R. Andersson, C. Johansson et al, CarbohydPolym, 96, 270 (2013), DOI: 10.1016/j.carbpol.2013.03.044
S. Denghani, S.V. Hosseini, and J.M. Regenstein, Food Chemistry, 240, 505 (2018), DOI: 10.1016/j.foodchem.2017.07.034
Kim, B.R., Yoo, J.-H., Jung, K.-S., Heu, S. G., & Lee, S.-Y., Journal of Food Hygiene and Safety, 27, 449(2012).
J. Uranga, A.I. Puertas, A. Etxabide, M.T. Dueñas, P. Guerrero, K. de la Caba, Food Hydrocolloids, 86, 95(2019), DOI: 10.1016/j.foodhyd.2018.02.018
L.Golbaghi, M. Khamforoush, and T. Hatami, Carbohydrate Polymers, 174, 780 (2017), DOI: 10.1016/j.carbpol.2017.06.123
P.Rachtanapun, S. Luangkamin, K. Tanprasert, R. Suriyatem, Food Science and Technology, 48(1), 52 (2012), DOI: 10.1016/j.lwt.2012.02.029
R. W. Eyler, E. D. Klug, and F. Diephuis, Analytical Chemistry, 19, 24(1947),DOI: 10.1021/ac60001a007
M. P.Adinugraha, D.W. Marseno, and Hayadi, Carbohydrate Polymers, 62(2), 164(2005), DOI: 10.1016/j.carbpol.2005.07.019
T.H.Heinze, And K. Pfelifer, Macromolecular Materials and Engineering, 266, 37 (1999), DOI:10.1002/(SICI)1522-9505(19990501)266:1<37::AID-APMC37>3.0.CO;2-Z
E. Sjostrom, Wood Chemistry Fundamentals and Applications second edition, Academic Press, Inc, United States, p.204,216(1993).
Sutradhar, S. Chandra, M.M.R. Khan, M.M. Rahman and N.C. Dafadar, Journal of Physical Science, 26(2), 23(2015)
B.Soni, Hassan, E. B., & Mahmoud, B. Carbohydrate Polymers, 134, 581(2015), DOI:10.1016/j.carbpol.2015.08.031
A.Salama, M. Neumann, C. Günter, and A. Taubert, Beilstein Journal of Nanotechnology, 5, 1553(2014), DOI: 10.3762/bjnano.5.167
P.Mario, D.W. Adinugrada, M. Haryadi, Carbohydr. Polym, 62(2), 164(2005), DOI: 10.1016/j.carbpol.2005.07.019
A.A.P.Mansur, F.G. de Carvalho, R.L. Mansur, S.M. Carvalho, L.C. de Oliveira, H.S. Mansur, Int. J. Biol. Macromol, 96, 675 (2017), DOI: 10.1016/j.ijbiomac.2016.12.078
R.M.Silverstein, G.C. Basser, and T.C. Masrill, Spectrometric Identification of Organic Compound, Fifth Edition, Jhon Wiley & Sons, Inc, New York, p. 1(1991).
H.M.C.Azeredo, C. Kontou-Vrettou, G.K. Moates, N. Wellner, K. Cross, P.H.F. Pereira, K.W. Waldron, Food Hydrocoll, 50, 1(2015), DOI: 10.1016/j.foodhyd.2015.04.005
N.S.V.Capanema, A.A.P. Mansur, A.C. de Jesus, S.M. Carvalho, L.C. de Oliveira, and H.S. Mansur, International Journal of Biological Macromolecules, 106, 1218(2017), DOI: 10.1016/j.ijbiomac.2017.08.124
M. D.Harun-or-Rashid, M. D. Saifur Rahaman, Shariff Enamul Kabir, Mubarak A Khan, J. Appl. Polym., 133(2), 1(2016), DOI: 10.1002/APP.42870
Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Fatimah Khaerani Siregar, Ardiansyah Ardiansyah, Atikah Asna
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
