Penyembuhan Luka Sayat menggunakan Gel Ekstrak Bawang Batak (Allium Chinense G. Don) : Studi Eksperimen pada Tikus Putih

Edward Waroka, Surya Dharma, Edy Fachrial

Abstract


The primary function of skin is to protect the inside of the body from physical and mechanical stresses. Skin is perceptive to its surroundings. Thus, a variety of skin issues may develop, including wounds. The standard wound treatment is chemical therapy using antiseptics. Antiseptics contain antimicrobial qualities that can eradicate bacteria. However, antiseptics can also destroy fibroblast tissue, which creates new skin tissue, and leukocytes, which are responsible for eliminating harmful bacteria. Alternative medicines, such as traditional medicine, are thus required to aid in wound healing. The purpose of this research is to determine the effectiveness of Allium chinense G. Don extract on the healing of cut wounds in white rats. This research is experimental research using a post-test control group design. Data analysis used One way ANOVA. The research found that Allium chinense G. Don extract contained alkaloids, flavonoids, saponins, and triterpenoids/steroids, but no tannin compounds. The antibacterial properties of Allium chinense G. Don are effective against Pseudomonas aeruginosa and Staphylococcus aureus bacteria. Collagen density and fibroblast count increased in Wistar rat wound tissue after being treated with the extract. Allium chinense G. Don is effective in healing cut wounds in white rats (p <0,001).


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Andriana, N., Lister, I. N. E., Fachrial, E., Ginting, C. N., & Lie, S. (2020). Effectiveness Test of Wound Healing based Virgin Coconut Oil toward Commercial Products on Rabbits. MECnIT 2020 - International Conference on Mechanical, Electronics, Computer, and Industrial Technology, 104–107. https://doi.org/10.1109/MECnIT48290.2020.9166656

Azizah, M., Lingga, L. S., & Rikmasari, Y. (2020). Uji Aktivitas Antibakteri Kombinasi Ekstrak Etanol Daun Seledri (Apium graviolens L.) Dan Madu Hutan Terhadap Beberapa Bakteri Penyebab Penyakit Kulit. Jurnal Penelitian Sains, 22(1), 37. https://doi.org/10.56064/jps.v22i1.547

Coarnita Girsang, L., Fachrial, E., Nyoman Ehrich Lister, I., & Sumatera, N. (2020). Effectiveness Test of Robusta Coffee (Coffea cenephora) Extract from North Sumatra in Collagen and Hydration Skin Level of Female Wistar Rattus norvegicus. Technology, and Sciences (ASRJETS) American Scientific Research Journal for Engineering, 65(1), 108–115. http://asrjetsjournal.org/

Dharma, S., Hapsari, R., Siswanto, B. B., van der Laarse, A., & Jukema, J. W. (2015). Blood Leukocyte Count on Admission Predicts Cardiovascular Events in Patients with Acute Non-ST Elevation Myocardial Infarction. The International journal of angiology : official publication of the International College of Angiology, Inc, 24(2), 127–132. https://doi.org/10.1055/s-0035-1544178

Fahmi, A. (2019). UJI AKTIVITAS ANTIBAKTERI EKSTRAK METANOL DAUN BAWANG BATAK (Allium chinense G. Don) TERHADAP Streptococcus mutans DAN Bacillus cereus SEBAGAI BAKTERI GRAM POSITIF. BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan), 6(2), 138–145. https://doi.org/10.31289/biolink.v6i2.2814

Harsa, I. M. S. (2020). Efek Pemberian Ekstrak Daun Pegagan (Centella Asiatica) Terhadap Penyembuhan Luka Sayat Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 9(1), 21. https://doi.org/10.30742/jikw.v9i1.664

Hartanto, S., Lister, I. N. E., & Fachrial, E. (2019). A Comparative Study of Peel and Seed Extract of Passion Fruit (Passiflora edulis) as Anti Collagenase. American Scientific Research Journal for Engineering, Technology, and Sciences, 54(1), 42–48. https://asrjetsjournal.org/index.php/American_Scientific_Journal/article/view/4722

Hasibuan, A. S., Edrianto, V., & Purba, N. (2020). SKRINING FITOKIMIA EKSTRAK ETANOL UMBI BAWANG MERAH (Allium cepa L.). Jurnal Farmasimed (Jfm), 2(2), 45–49. https://doi.org/10.35451/jfm.v2i2.357

Indryani Fauhan, K., Ehrich Lister, I. N., & Fachrial, E. (2023). The Use of Rosella (Hibiscus sabdariffa L.) Extract Cream to Prevent Decreasing of Total Collagen in the Skin of Wistar Rats Exposed to Ultraviolet-B Light. Journal of Pharmaceutical Research International, 35(1), 24–32. https://doi.org/10.9734/jpri/2023/v35i17301

Kemenkes RI. (2017). Farmakope Herbal Indonesia Edisi 2. Kementerian Kesehatan Republik Indonesia, Jakarta

Malo, G., Saputro, I. P., & Turang, R. (2019). Sistem Pakar Diagnosis Penyakit Kulit Menggunakan Metode Certainty Factor. Jurnal Ilmiah Realtech, 15(1), 13–18. https://doi.org/10.52159/realtech.v15i1.76

Nurhayati, L. S., Yahdiyani, N., & Hidayatulloh, A. (2020). Perbandingan Pengujian Aktivitas Antibakteri Starter Yogurt dengan Metode Difusi Sumuran dan Metode Difusi Cakram. Jurnal Teknologi Hasil Peternakan, 1(2), 41. https://doi.org/10.24198/jthp.v1i2.27537

Rafif Putranta, N., & Kurniawaty, E. (2019). Potensi Biopolimer Kitosan Dalam Pengobatan Luka. Jurnal Medula, 9(3), 459–464. https://juke.kedokteran.unila.ac.id/index.php/medula/article/view/2547

Rahmawaty, A. (2020). Peran Perawatan Kulit (Skincare) Yang Dapat Merawat Atau Merusak Skin Barrier. Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI), 7(1), 005–010. https://doi.org/10.48177/bimfi.v7i1.32

Sangkoy, W. J., Simbala, H. E. I., & Rumondor, E. M. (2023). Aktivitas antibakteri ekstrak etanol daun pinang yaki (Areca vestiaria) terhadap bakteri Staphylococcus aureus, Escherichia coli, dan Pseudomonas aeruginosa. Pharmacon, 12(1), 133–139.

Sarmira, M.-, Purwanti, S.-, & Yuliati, F. N. (2021). Aktivitas antibakteri ekstrak daun oregano terhadap bakteri Escherichia coli dan Stapylococcus aureus sebagai alternatif feed additive unggas. Jurnal Ilmu Ternak Universitas Padjadjaran, 21(1), 40. https://doi.org/10.24198/jit.v21i1.33161

Tutik, T., Feladita, N., & Evaliana, K. (2022). FORMULASI SEDIAAN GEL EKSTRAK KULIT BAWANG MERAH (Allium cepa L.) SEBAGAI ANTIJERAWAT TERHADAP BAKTERI Propionibacterium acnes. Jurnal Farmasi Malahayati, 4(2), 173–184. https://doi.org/10.33024/jfm.v4i2.5290

Wiriandini, E., Dalimunthe, G. I., Lubis, M. S., & Nasution, H. M. (2024). Uji Aktivitas Antibakteri Sabun Transparan Putik Saffron (Crocus sativus L) terhadap Bakteri Staphylococcus aureus. OBAT: Jurnal Riset Ilmu Farmasi Dan Kesehatan, 2(2), 203–220.

Wintoko, R., & Yadika, A. D. N. (2020). Manajemen Terkini Perawatan Luka. Jurnal Kedokteran Universitas Lampung, 4(2), 183–189.




DOI: http://dx.doi.org/10.30829/jumantik.v10i1.21604

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