Perbandingan Jumlah Leukosit pada Anak yang Menderita DBD dengan Syok dan tanpa Syok di RSUD Dr H Chasan Boesoirie Ternate Periode Januari-Desember 2020

Jihan Ichsan, Husain Assagaf, Eko Sudarmo D Prihanto


Dengue hemorrhagic fever (DHF), a dengue virus infection transmitted by Aedes aegypti mosquito, has become one of the main global diseases. White blood cell count is one of laboratory parameters examined on DHF with daily variation. The purpose is to identify the white blood cell count comparison between pediatric DHF patient with and without shock  based on the day of illness. On this retrospective cross-sectional analytic study, the study subjects were DHF patients aged 1-17 years old with and without shock according to the WHO 2011 criteria. Secondary data was obtained from medical record of patients admitted in the pediatric ward, dr H Chasan Boesoirie General Hospital, in January-December 2020. The Mann-Whitney statistical test was utilized to analyze white blood cell count and patient’s characteristics The white blood cell average count of DHF patients with shock decreased on day 3 of illness, reached the lowest point on day 4 of illness (2220/mm3) and increased on day 5 of illness (6585/mm3). The white blood cell average count of DHF patients without shock tends to be stable day by day. Regarding the while blood cell count comparison between DHF with and without shock patients, statistical significance was only identified on fever day 6 (p=0,026). So, there was a significant difference of average white blood cell count of DHF with and without shock on day 6 of illness.


Keywords: Dengue Hemorrhagic Fever, Shock, White Blood Cell.

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Chen, C. H., Huang, Y. C., Kuo, K. C., & Li, C. C. (2018). Clinical features and dynamic ordinary laboratory tests differentiating dengue fever from other febrile illnesses in children. Journal of Microbiology, Immunology and Infection, 51(5), 614–620.

Dantés, H. G., Farfán-Ale, J. A., & Sarti, E. (2014). Epidemiological Trends of Dengue Disease in Mexico (2000–2011): A Systematic Literature Search and Analysis. PLoS Neglected Tropical Diseases, 8(11).

Dwi, I. M., Adnyana, M., Luh, N., Sudaryati, G., & Suardana, A. A. K. (2021). Blood smear profile of patients with dengue hemorrhagic fever in bali royal hospital. Journal of Vocational Health Studies, 05, 39–46.

Harapan, H., Michie, A., Mudatsir, M., Sasmono, R. T., & Imrie, A. (2019). Epidemiology of dengue hemorrhagic fever in Indonesia: Analysis of five decades data from the National Disease Surveillance. BMC Research Notes, 12(1), 4–9.

Jabeen, U., Iftikhar, A., Hamid, M. H., & Chaudhry, A. (2018). Comparison of characteristics of dengue hemorrhagic fever in children during 2011 and 2013 outbreaks. Pakistan Paediatric Journal, 42(2), 95–101.

Jayawinata, M., Rusli, M., & Yotopranoto, S. (2017). Hubungan Perubahan Jumlah Leukosit dengan Derajat Klinik Penderita Rawat Inap DBD Dewasa. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 9(1), 14–19.

Kementerian Kesehatan Republik Indonesia. (2016). Profil Kesehatan Indonesia 2016 (R. Kurniawan, Yudianto, B. Hardhana, & T. Soenardi (eds.)). Kementerian Kesehatan Republik Indonesia.

Podung, G. C. ., Tatura, S. N. ., & Mantik, M. F. . (2021). Faktor Risiko Terjadinya Sindroma Syok Dengue pada Demam Berdarah Dengue. Jurnal Biomedik : Jbm, 13(2), 161–166.

Primadi, O., & Budijanto, D. (2010). Profil Kesehatan Indonesia Tahun 2019. In B. Hardhana, F. Sibuea, & W. Widiantini (Eds.), Short Textbook of Preventive and Social Medicine (2020th ed.). Kementerian Kesehatan Republik Indonesia.

Raihan, Fitriani, E., & Herawati. (2020). Analisis Faktor Risiko Terjadinya Syok pada Anak dengan Demam Berdarah Dengue di RSUD dr . Zainoel Abidin. Journal of Medical Science, 2(1), 74–80.

Rosdiani, Y. A., Indriyanti, R. A., & Dananjaya, R. (2019). Hubungan Tingkat Trombositopenia dan Kadar Leukosit terhadap Dengue Shock Syndrome pada Anak Usia 5-14 Tahun Periode 1 Januari 2014–31 Mei 2016 di Rsud Al-Ihsan Provinsi Jawa Barat. 1056–1063.

Soedarmo, S. S. P. (2015). Buku Ajar Infeksi dan Pediatri Tropis (Edisi Kedu). Badan Penerbit Ikatan Dokter Anak Indonesia.

Triana, D., Kurniati, A., & Wirastari, G. G. (2020). Relationship Between Platelet, Hematocrit and Leukocyte with Dengue Severity in Bengkulu City, Indonesia. European Journal of Molecular & Clinical Medicine, 7(10), 2305–2311.

Wang, W. H., Urbina, A. N., Chang, M. R., Assavalapsakul, W., Lu, P. L., Chen, Y. H., & Wang, S. F. (2020). Dengue hemorrhagic fever – A systemic literature review of current perspectives on pathogenesis, prevention and control. Journal of Microbiology, Immunology and Infection, 53(6), 963–978.

WHO. (2011). Comprehensive guidelines for prevention and control of dengue and dengue haemorrhagic fever. In C. Prasittisuk, N. L. Kalra, & A. P. Dash (Eds.), WHO Regional Publication SEARO (WHO South-, Issue 1). World Health Organization.

WHO. (2012). Global Strategy For Dengue Prevention And Control 2012-2020 (WHO Member State (ed.)). World Health Organization.



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