Inhalation of Orange Peel Aroma: Study on the Effects of Exotic Oils on Blood Pressure Changes
Abstract
Oranges are a fruit that is in great demand by the public. Oranges have a sweet taste and distinctive aroma. Orange peel debris is one of the problems that is of concern to the government. This is because there are still many people who do not use it and just throw it away. This is because many people still don't know that orange peel waste contains the active substance d-lemonene. The d-lemonene compound is a compound that has a fragrant and refreshing aroma, so it can provide a calming feeling to those who inhale it. Therefore, this study aims to see the effect of the fragrant aroma of raw orange peel extract on changes in blood pressure. The extraction method used is steam distillation in order to maximize the yield obtained. After obtaining the raw extract, it was characterized using Gas Chromatography Mass Spectrometry (GC-MS) to determine the skin content. The research results showed that the yield of orange peel extract calculated based on the volume of extraction results divided by the sample weight in grams was 20% (v/w). Based on the results of Gas Chromatography Mass Spectrometry (GC-MS) characterization, it shows that the sample contains the compound d-lemonene. The effectiveness test showed a decrease in blood pressure in respondents who had high blood pressure and an increase in pressure in respondents who had low blood pressure. The reason is that the d-lemonene compound contained in orange peel can provide a calming sensation. This can happen because the d-lemonene compound is able to inhibit neuroinflammation and nitrite levels in the hippocampus and relieve anxiety through DAergic and GABAergic nerve activity mediated by A2A receptors.
Keywords: Blood Pressure, Essencial Oil, Orange Peel
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Adetuyi, B. O., Olajide, P. A., Adetunji, C. O., Adetunji, J. B., Popoola, O. A., Ajenifujah-Solebo, O., Godwin, Y. D., Kolawole, O. M., Akinbo, O., & Inobeme, A. (2024). Application of essential oil in aromatherapy: current trends. Applications of Essential Oils in the Food Industry, 207–221. doi: 10.1016/B978-0-323-98340-2.00011-0
Araújo-Filho, H. G., Pereira, E. W. M., Heimfarth, L., Souza Monteiro, B., Santos Passos, F. R., Siqueira-Lima, P., Gandhi, S. R., Viana dos Santos, M. R., Guedes da Silva Almeida, J. R., Picot, L., Grougnet, R., Almeida, R. S., Douglas Melo Coutinho, H., Quintans-Júnior, L. J., Martins, N., & Quintans, J. S. S. (2020). Limonene, a food additive, and its active metabolite perillyl alcohol improve regeneration and attenuate neuropathic pain after peripheral nerve injury: Evidence for IL-1β, TNF-α, GAP, NGF and ERK involvement. International Immunopharmacology, 86, 106766. doi: 10.1016/J.INTIMP.2020.106766
Baroroh, S. Q., & Fauziyah, E. (2021). Manajemen Risiko Usahatani Jeruk Nipis di Desa Kebonagung Kecamatan Ujungpangkah Kabupaten Gresik. Jurnal Ekonomi Pertanian Dan Agribisnis, 5(2), 494–509. doi: 10.21776/UB.JEPA.2021.005.02.18
Burnier, M., Prejbisz, A., Weber, T., Azizi, M., Cunha, V., Versmissen, J., Gupta, P., Vaclavik, J., Januszewicz, A., Persu, A., & Kreutz, R. (2021). Hypertension healthcare professional beliefs and behaviour regarding patient medication adherence: a survey conducted among European Society of Hypertension Centres of Excellence. Blood Pressure, 30(5), 282–290. doi: 10.1080/08037051.2021.1963209
Carlsson, M., Brudin, L., Darwiche, G., Catic Cuti, E., Kovacevic, I., Cuti, T., Burkard, T., Hug, R., Meienberg, A., Socrates, T., Mayr, M., & Vischer, A. (2021). Potential Of Aromatherapy As A Lifestyle Measure In Blood Pressure Reduction: An Ancient Practice Incorporated In Modern Medicine: Pilot Project. Retrieved from http://journals.lww.com/jhypertension
Chen, B., Liu, C., Shang, L., Guo, H., Qin, J., Ge, L., Jing, C. J., Feng, C., & Hayashi, K. (2019). Electric-field enhancement of molecularly imprinted sol–gel-coated Au nano-urchin sensors for vapor detection of plant biomarkers. Journal of Materials Chemistry C, 8(1), 262–269. doi: 10.1039/C9TC05522C
Chiu, C. S., Huang, P. H., Chan, Y. J., Li, P. H., & Lu, W. C. (2024). d-limonene nanoemulsion as skin permeation enhancer for curcumin prepared by ultrasonic emulsification. Journal of Agriculture and Food Research, 15, 100932. doi: 10.1016/J.JAFR.2023.100932
de Sousa, D. P., Damasceno, R. O. S., Amorati, R., Elshabrawy, H. A., de Castro, R. D., Bezerra, D. P., Nunes, V. R. V., Gomes, R. C., & Lima, T. C. (2023). Essential Oils: Chemistry and Pharmacological Activities. Biomolecules, 13(7), 1144. doi: 10.3390/biom13071144
Dehghan, N., Azizzadeh Forouzi, M., Etminan, A., Roy, C., & Dehghan, M. (2022a). The effects of lavender, rosemary and orange essential oils on memory problems and medication adherence among patients undergoing hemodialysis: A parallel randomized controlled trial. EXPLORE, 18(5), 559–566. doi: 10.1016/j.explore.2021.10.004
Dehghan, N., Azizzadeh Forouzi, M., Etminan, A., Roy, C., & Dehghan, M. (2022b). The effects of lavender, rosemary and orange essential oils on memory problems and medication adherence among patients undergoing hemodialysis: A parallel randomized controlled trial. EXPLORE, 18(5), 559–566. doi: 10.1016/J.EXPLORE.2021.10.004
Eddin, L. B., Jha, N. K., Meeran, M. F. N., Kesari, K. K., Beiram, R., & Ojha, S. (2021). Neuroprotective Potential of Limonene and Limonene Containing Natural Products. Molecules 2021, Vol. 26, Page 4535, 26(15), 4535. doi: 10.3390/MOLECULES26154535
Erba, O., Atomsa, D., Chimdessa, M., & Gonfa, T. (2020). Determination of Flavonoid Contents and Evaluation of in vitro Antioxidant Activities of the Extract of Selected Citrus Fruit Peel. International Journal of Secondary Metabolite, 7(1), 8–18. doi: 10.21448/IJSM.660578
Fadlilah, S., Rahil, N. H., & Lanni, F. (2020). Analisis Faktor Yang Mempengaruhi Tekanan Darah Dan Saturasi Oksigen Perifer (SPO2). Jurnal Kesehatan Kusuma Husada, 21–30. doi: 10.34035/JK.V11I1.408
Goes, T. C., Antunes, F. D., Alves, P. B., & Teixeira-Silva, F. (2012). Effect of Sweet Orange Aroma on Experimental Anxiety in Humans. Https://Home.Liebertpub.Com/Acm, 18(8), 798–804. doi: 10.1089/ACM.2011.0551
Heydari, N., Abootalebi, M., Jamalimoghadam, N., Kasraeian, M., Emamghoreishi, M., & Akbarzadeh, M. (2018). Investigation of the effect of aromatherapy with Citrus aurantium blossom essential oil on premenstrual syndrome in university students: A clinical trial study. Complementary Therapies in Clinical Practice, 32, 1–5. doi: 10.1016/J.CTCP.2018.04.006
Hien, T. T., Binh, H. Q., Long, H. B., & Le, X. T. (2022). Evaluation of Influencing Factors and Technological Processes for the Production of Orange Essential Oil on Equipment Semi-industrial Distillation. Indonesian Journal of Chemistry, 22(1), 742. doi: 10.22146/ijc.70467
Kaswindiarti, S., & Khotimah, T. H. (2021). Pengaruh Aromaterapi Jeruk Manis (Citrus Sinensis) Terhadap Penurunan Tekanan Darah Dan Denyut Nadi Anak Usia 6-9 Tahun Pada Kunjungan Pertama Ke Dokter Gigi. JIKG (Jurnal Ilmu Kedokteran Gigi), 3(2). doi: 10.23917/JIKG.V3I2.12469
Kohli, D., Sundriyal, J., Kumar, S., Upadhyay, S., & Hussain, A. (2024). Investigating the antioxidant capacity of orange peel extract and its application in shelf-life extension of ghee. Journal of Stored Products Research, 107, 102349. doi: 10.1016/J.JSPR.2024.102349
Lorigooini, Z., Boroujeni, S. N., Sayyadi-Shahraki, M., Rahimi-Madiseh, M., Bijad, E., & Amini-Khoei, H. (2021). Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress. doi: 10.1155/2021/8817309
Mahendra, Y. P., Purwono, J., Ayubbana, S., Akademi, M., Dharma, K., Metro, W., & Akademi, D. (2021). Penerapan Aroma Terapi Mawar Terhadap Penurunan Tekanan Darah Tinggi Pada Pasien Hipertensi Application Of Rose Aroma Therapy To Reduction Of High Blood Pressure In Hypertension Patients. Jurnal Cendikia Muda, 1(2).
Marfu’ah, S., Fajaroh, F., Romadhona, W. A., & Dwi Taufina, D. (2020). Aktivitas Ekstrak Kulit Jeruk Manis sebagai Antioksidan dan Toksisitasnya Terhadap Artemia Salina. Journal Cis-Trans), 4(2), 7–14. doi: 10.17977/um0260v4i22020p007
Nakamura, K., Suzuki, Y., Goto, K., Yamaguchi, S., & Hiramitsu, M. (2023). Antihypertensive and Vasorelaxant Effects of Citric Acid and Lemon Juice in Spontaneously Hypertensive Rats: In Vivo and Ex Vivo Studies. Nutrients, 15(17), 3849. doi: 10.3390/nu15173849
Pagliaro, M., Fabiano-Tixier, A. S., & Ciriminna, R. (2023). Limonene as a natural product extraction solvent. Green Chemistry, 25(16), 6108–6119. doi: 10.1039/D3GC02068A
Patterson, C. C., Linden, G. J., Moitry, M., Biasch, K., Kee, F., Amouyel, P., Bongard, V., Dallongeville, J., Ferrières, J., & Woodside, J. V. (2021). Association between overall fruit and vegetable intake, and fruit and vegetable sub-types and blood pressure: the PRIME study (Prospective Epidemiological Study of Myocardial Infarction). British Journal of Nutrition, 125(5), 557–567. doi: 10.1017/S0007114520001518
Putra, S. (2022). Pengaruh Gaya Hidup Dengan Kejadian Hipertensi di Indonesia (A: Systematic Review). Jurnal Pendidikan Tambusai, 6(2), 15794–15798. doi: 10.31004/JPTAM.V6I2.4295
Putri, N. T., & Putri, U. R. (2020). Pengaruh Hydrotherapy Ekstrak Kulit Jeruk (Citrus Limon) Terhadap Penurunan Tekanan Darah Pada Lansia. Maternal Child Health Care, 2(2), 273. doi: 10.32883/MCHC.V2I2.1041
Roswita, R., Kemenkes, P., Jln, B., Mistar Cokrokusumo, H., & 1a Banjarbaru, N. (2022). Pengaruh Aromaterapi Terhadap Penurunan Tekanan Darah Pada Pasien Dengan Hipertensi : Literature Review. Jurnal Skala Kesehatan, 13(2), 122–130. doi: 10.31964/JSK.V13I2.368
Sawicka, K., Szczyrek, M., Jastrzębska, I., Prasał, M., Zwolak, A., & Daniluk, J. (2011). Hypertension-The Silent Killer. Journal of Pre-Clinical and Clinical Research, 5(2), 43–46. Retrieved from www.jpccr.eu
Siwi, A. S., Irawan, D., & Susanto, A. (2020). Analisis Faktor-Faktor yang Memengaruhi Kejadian Hipertensi. Journal of Bionursing, 2(3), 164–166. doi: 10.20884/1.BION.2020.2.3.70
Song, Y., Seo, S., Lamichhane, S., Seo, J., Hong, J. T., Cha, H. J., & Yun, J. (2021). Limonene has anti-anxiety activity via adenosine A2A receptor-mediated regulation of dopaminergic and GABAergic neuronal function in the striatum. Phytomedicine, 83, 153474. doi: 10.1016/J.PHYMED.2021.153474
Soraya, U., Tafwidhah, Y., Sri, B., & Adiningsih, U. (2014). Pengaruh Aromaterapi Lavender Terhadap Penurunan Tekanan Darah Pada Lansia Dengan Hipertensi Di Kelurahan Siantan Hulu Pontianak Utara.
Subantara, D. O., Nurachmah, E., Dahlia, D., & Maria, R. (2022). Pengaruh Cold Pressure Test Pada Tekanan Darah. Jurnal Keperawatan Silampari, 5(2), 1170–1180. doi: 10.31539/jks.v5i2.3654
Sulyanti, E., Yaherwandi, Y., & Ulindari, R. M. (2019). Aktivitas Air Rebusan Beberapa Kulit Jeruk (Citrus spp) untuk Menekan Pertumbuhan Colletotrichum gloeosporioides pada Tanaman Buah Naga secara In Vitro. JPT : Jurnal Proteksi Tanaman (Journal Of Plant Protection), 3(2), 56. doi: 10.25077/jpt.3.2.56-64.2019
Udayani, N. N. W., Wiguna, P. D. S., Cahyaningsih, E., & Wardani, I. G. A. A. K. (2023). Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Daun Benalu Jeruk (Dendrophthoe glabrescens (Blakely) Barlow) dengan Pelarut n-Heksan dan Etanol. Jurnal Ilmiah Medicamento, 9(2), 150–157. doi: 10.36733/medicamento.v9i2.7136
Vora, L. K., Gholap, A. D., Hatvate, N. T., Naren, P., Khan, S., Chavda, V. P., Balar, P. C., Gandhi, J., & Khatri, D. K. (2024). Essential oils for clinical aromatherapy: A comprehensive review. Journal of Ethnopharmacology, 330, 118180. doi: 10.1016/J.JEP.2024.118180
Williams, B., Mancia, G., Spiering, W., Rosei, E. A., Azizi, M., Burnier, M., Clement, D. L., Coca, A., De Simone, G., Dominiczak, A., Kahan, T., Mahfoud, F., Redon, J., Ruilope, L., Zanchetti, A., Kerins, M., Kjeldsen, S. E., Kreutz, R., Laurent, S., … Zamorano, J. L. (2018). ESC/ESH Guidelines for the management of arterial hypertension. In European Heart Journal (Vol. 39, Issue 33, pp. 3021–3104). Oxford University Press. doi: 10.1093/eurheartj/ehy339
Zaki, A. H., Saleh Gazwi, H. S., Hamed, M. M., Galal, S. M., Almehmadi, A. M., Almuraee, A. A., Alqurashi, A. F., & Yassien, E. E. (2024). The synergistic potential of orange peel extract: A comprehensive investigation into its phenolic composition, antioxidant, antimicrobial, and functional fortification properties in yogurt. Food Chemistry: X, 22, 101458. doi: 10.1016/J.FOCHX.2024.101458
DOI: http://dx.doi.org/10.30829/contagion.v6i2.21175
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