Dosage Evaluation and Antioxidant Activity Test of Lotion of Ethanol Extract of Belimbing Wuluh Leaf (Averrhoa Bilimbi L.)
Abstract
This study aims to make and evaluate the lotion formula from ethanol extract of star fruit leaves (Averrhoa bilimbi L.) and test the antioxidant activity of the lotion. The research method used is experimental, making lotions and testing antioxidant activity from July to October 2023 at the Semi-Solid Preparation Technology Laboratory, Department of Pharmacy, Poltekkes Kemenkes Medan, and Research Laboratory, University of North Sumatra. In the preparation stage, star fruit leaf simplisia was extracted by maceration using a 95% ethanol solvent. The lotion formula was made with ingredients such as PEG 4000, stearyl alcohol, glycerin, sodium lauryl sulfate, coconut oil, nipagin, and distillate water, with varying concentrations of ethanol extract of star fruit leaves. The formulation was evaluated through organoleptic, homogeneity, pH, spreadability, and viscosity tests. The results showed that the lotion produced had a homogeneous shape and aroma to the concentration of ethanol extract. In addition, the pH of the lotion is also within the safe range for human skin. The spreadability test showed the lotion's ability to spread on the skin, which met the requirements for lotions with spreadability values between 5 and 7 cm. The viscosity of the lotion was also by the set standards. Stability tests were conducted to monitor the physical and chemical changes of the lotion over four weeks. The results showed that lotions with 1% and 3% ethanol extract concentrations were stable during the study period. However, the 5% concentration experienced inhomogeneity changes in the third week. In conclusion, lotion with ethanol extract of star fruit leaves at 1% and 3% concentration can produce a good and stable formula. However, the antioxidant activity of the lotion is still in the weak to moderate category. This research contributes to developing plant-based natural cosmetic products for skin care.
Keywords: Antioxidant Activity, Belimbing Wuluh, Ethanol Extract, Evaluation, Lotion
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amira, K. J. (2021). Formulasi Sediaan Serum Dari Ekstrak Buah Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Propionibacterium Acnes Secara In Vitro. Paper Knowledge . Toward A Media History Of Documents, 3(2), 6.
Ariem, F., Yamlean, P. V. ., & Lebang, J. S. (2020). Formulasi Dan Uji Efektivitas Antioksidan Sediaan Krim Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa Bilimbi L. ) Dengan Menggunakan Metode Dpph (1,1-Diphenyl-2-Picrylhydrazyl). Pharmacon, 9(4), 501. Https://Doi.Org/10.35799/Pha.9.2020.31355
Arisanty, A., & Anita, A. (2018). Uji Mutu Fisik Sediaan Krim Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa Bilimbi L.) Dengan Variasi Konsentrasi Na. Lauril Sulfat. Media Farmasi, 14(1), 22. Https://Doi.Org/10.32382/Mf.V14i1.80
Dominica, D., & Handayani, D. (2019). Formulasi Dan Evaluasi Sediaan Lotion Dari Ekstrak Daun Lengkeng (Dimocarpus Longan) Sebagai Antioksidan. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 6(1), 1. Https://Doi.Org/10.20473/Jfiki.V6i12019.1-7
Febriyanti, D., Halimatushadyah, E., Waluyo, D. A., & Rahma, K. (2024). Formulasi Dan Uji Aktivitas Krim Antijerawat Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Staphylococcus Epidermidis. Cerata Jurnal Ilmu Farmasi, 14(2), 132–143. Https://Doi.Org/10.61902/Cerata.V14i2.857
Hasim, H., Arifin, Y. Y., Andrianto, D., & Faridah, D. N. (2019). Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa Bilimbi) Sebagai Antioksidan Dan Antiinflamasi. Jurnal Aplikasi Teknologi Pangan, 8(3), 86. Https://Doi.Org/10.17728/Jatp.4201
Hosni, S., Gani, S. S. A., Orsat, V., Hassan, M., & Abdullah, S. (2023). Ultrasound-Assisted Extraction Of Antioxidants From Melastoma Malabathricum Linn.: Modeling And Optimization Using Box–Behnken Design. Molecules, 28(2), 307–315. Https://Doi.Org/10.3390/Molecules28020487
Ismail, D. D. (2022). Formulasi Dan Uji Aktivitas Gel Ekstrak Etanol 96% Daun Belimbing Wuluh (Averrhoa Bilmbi Linn) Terhadap Bakteri Staphylococcus Epidermidis. Indonesia Natural Research Pharmaceutical Journal, 7(1), 32–43. Https://Doi.Org/10.52447/Inrpj.V7i1.5931
Jamil, S. A., Rahayu, Y. P., Lubis, M. S., & Nasution, H. M. (2023). Uji Aktivitas Antibakteri Formulasi Sediaan Sabun Padat Transparan Ekstrak Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Terhadap Bakteri Cutibacterium Acnes. Journal Of Pharmaceutical And Sciences, 6(4), 1568–1577. Https://Doi.Org/10.36490/Journal-Jps.Com.V6i4.234
Kurniawati, E. (2017). Daya Antibakteri Ekstrak Etanol Tunas Bambu Apus Terhadap Bakteri Escherichia Coli Dan Staphylococcus Aureus Secara In Vitro. Jurnal Wiyata, 2(2), 193–199. Https://Ojs.Iik.Ac.Id/Index.Php/Wiyata/Article/View/60/60
Mayaranti Wilsya, Sigit Cahyo Hardiansyah, & Desy Pratama Sari. (2020). Formulasi Dan Uji Aktivitas Antioksidan Lotion Ekstrak Daun Gandarusa (Justicia Gendarussa Burm F.). Jurnal Kesehatan : Jurnal Ilmiah Multi Sciences, 10(02), 105–115. Https://Doi.Org/10.52395/Jkjims.V10i02.292
Mayaranti Wilsya, Yeni Agustin, & Adellia Muharyati. (2022). Formulasi Sediaan Lotion Kombinasi Ekstrak Daun Sirsak (Annona Muriacata L) Dan Ekstrak Daun Nangka (Artocarpus Heterophyllus Lam) Sebagai Pelembab. Jurnal Kesehatan : Jurnal Ilmiah Multi Sciences, 12(02), 80–87. Https://Doi.Org/10.52395/Jkjims.V12i02.348
Megasari, D. S. 2020. (N.D.). Kajian Penerapan Model Pembelajararan Kooperatif Tipe True Or False Pada Kompetensi Dasar Kelainan Dan Penyakit Kulit.
Muharyati, A. (2022). Pengaruh Variasi Emulgator Terhadap Sediaan Lotion Ekstrak Daun Sirsak (Annona Muricata L) Dan Ekstrak Daun Nangka (Artocarpus Heterophyllus Lam). הארץ, 2(8.5.2017), 2003–2005.
Naiu, A. S., & Yusuf, N. (2018). Nilai Sensoris Dan Viskositas Skin Cream Menggunakan Gelatin Tulang Tuna Sebagai Pengemulsi Dan Humektan. Jurnal Pengolahan Hasil Perikanan Indonesia, 21(2), 199. Https://Doi.Org/10.17844/Jphpi.V21i2.22838
Nara, Ayu, L. (2019). Formulasi Lip Cream Ekstrak Etanol Kulit Buah Terong Belanda (Solanum Betaceum) Sebagai Pewarna Alami. Fakultas Farmasi Dan Kesehatan Helvetia, Medan., Hlm. 1-88.
Ningsih, A. W., Klau, I. C. S., & Wardani, E. P. (2021). Studi Formulasi Hand Body Lotion Ekstrak Etanol Kunyit (Curcuma Domestica Val.). Farmasis: Jurnal Sains Farmasi, 2(1), 32–37. Https://Doi.Org/10.36456/Farmasis.V2i1.3621
Riyanti, S., Sulastri, L., Rizikiyan, Y., & Prayoga, I. B. (2022). Formulasi Dan Uji Stabilitas Lotion Ekstrak Kulit Buah Matoa (Pometia Pinnata J.R & G. Forst) Konsentrasi 1,5% Dan 2%. Medimuh : Jurnal Kesehatan Muhammadiyah, 3(1), 11–20.
Surya, A., Jose, C., & Teruna, Yuda, H. (2013). Studi Aktivitas Antioksidan Dari Ekstrak Metanol Dan Etil Asetat Pada Daun Bangun-Bangun (Plectranthus Amboinicus). Indonesian Chemia Acta, 4(1), 12–16. Https://Festiva.Ejournal.Unri.Ac.Id/Index.Php/Ica/Article/View/1867
Verawaty, V., Dewi, I. P., & Ch, F. F. (2020). Formulasi Dan Evaluasi Gel Infusa Daun Belimbing Wuluh. Jurnal Farmasi Higea, 12(2), 178–184. Http://Www.Jurnalfarmasihigea.Org/Index.Php/Higea/Article/View/309
Vinaeni, A. R., Anindhita, M. A., & Ermawati, N. (2022). Formulasi Hand And Body Lotion Ekstrak Daun Sambiloto Dengan Setil Alkohol Sebagai Stiffening Agent. Cendekia Journal Of Pharmacy, 6(1), 65–75. Https://Doi.Org/10.31596/Cjp.V6i1.147
Widyastuti, Kusuma, & Sukmawati. (2016). Aktivitas Antioksidan Dan Tabir Surya Ekstrak Etanol Daun Stroberi (Fragaria X Ananassa An Duchesne). Jurnal Sains Farmasi & Klinis, 3(1), 19–24. Http://Jsfk.Ffarmasi.Unand.Ac.Id/Index.Php/Jsfk/Article/View/92/0
Wintariani, N. P., Mahartha, I. K. P., & Suwantara, I. P. T. (2021). Sifat Fisika Kimia Sediaan Vanishing Krim Anti Jerawat Ekstrak Etanol 96% Daun Belimbing Wuluh (Averrhoa Bilimbi L.). Widya Kesehatan, 3(1), 26–34. Https://Doi.Org/10.32795/Widyakesehatan.V3i1.1655
Yuliana, B., Hasan, T., Habar, A., & Suleman, A. W. (2023). Formulasi Dan Uji Antioksidan Krim Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Menggunakan Metode Dpph. Medical Sains : Jurnal Ilmiah Kefarmasian, 8(3), 1229–1240. Https://Doi.Org/10.37874/Ms.V8i3.706
Zaky, M., Rusdiana, N., & Darmawati, A. (2021). Formulasi Dan Evaluasi Fisik Sediaan Gel Antioksidan Ekstrak Etanol 70% Daun Belimbing Wuluh (Averrhoa Bilimbi L.) Menggunakan Metode Dpph. Jurnal Farmagazine, 8(2), 26. Https://Doi.Org/10.47653/Farm.V8i2.556
DOI: http://dx.doi.org/10.30829/contagion.v6i1.19224
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