Effect of Vitamin D3 on Changes in Muscle Mass in the Elderly in Nursing Homes: Double-Blind Controlled Randomized Trial

Prajna Adhityarani, Diana Sunardi, Esthika Dewiasty

Abstract


The decline in muscle mass and strength begins at the age of 30 years by 40% within 30 years, then will decrease by 40% every ten years after the age of 60 years. Loss of muscle mass and strength in older people causes weakness and reduced muscle function, which can lead to a decrease in the ability to perform activities of daily living and an increased risk of falls. In addition, older people are prone to malnutrition; this condition will be accompanied by micronutrient deficiencies both in older people who are undernourished and overnourished. Giving vitamin D3 to increase muscle mass and ability and reduce fat mass in older people also has pros and cons. So, this study aims to explore the effect of giving Vitamin D3 on changes in muscle mass in older adults. The study will also examine changes in upper arm muscle strength and evaluate the impact of Vitamin D3 on changes in muscle mass. This research is a study with an Experimental Randomised Control Trial (RCT) research design. The population was elderly who were deficient in vitamin D, while the study sample amounted to 26 control subjects and 26 action subjects. Samples are taken by consecutive sampling technique. Based on research findings, most older adults (60–69 years) suffer from vitamin D deficiency and deficiency. However, vitamin D3 supplementation increases the muscle mass of older adults in nursing homes, especially in the muscles of the upper and lower extremities. However, the supplement weakens muscle mass and causes bruising and bleeding but does not weaken arm muscle mass.

 

Keywords: Elderly,  Muscle Mass,  Panti Werdha, Vitamin D3

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References


Badan Pusat Statistik. (2020). Statistik Penduduk Lanjut Usia.

Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., Ceda, G. P., De Vito, G., Donders, G., Drey, M., Greig, C., Holmbäck, U., Narici, M., McPhee, J., Poggiogalle, E., … Cederholm, T. (2015). Effects of a Vitamin D and Leucine-Enriched Whey Protein Nutritional Supplement on Measures of Sarcopenia in Older Adults, the PROVIDE Study: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of the American Medical Directors Association, 16(9), 740–747. https://doi.org/10.1016/j.jamda.2015.05.021

Biben, V., Defi, I. R., Nugraha, G. I., & Setiabudia, B. (2017). Vitamin D Status and its Impact on Body Composition in Elderly Community-dwelling Individuals in Bandung and Sumedang, West Java Province, Indonesia. Asian Journal of Epidemiology, 10(2), 63–69. https://doi.org/10.3923/aje.2017.63.69

Bislev, L. S., Grove‐Laugesen, D., & Rejnmark, L. (2021). Vitamin D and Muscle Health: A Systematic Review and Meta‐analysis of Randomized Placebo‐Controlled Trials. Journal of Bone and Mineral Research, 36(9), 1651–1660. https://doi.org/10.1002/jbmr.4412

Bo, Y., Liu, C., Ji, Z., Yang, R., An, Q., Zhang, X., You, J., Duan, D., Sun, Y., Zhu, Y., Cui, H., & Lu, Q. (2019). A high whey protein, vitamin D and E supplement preserves muscle mass, strength, and quality of life in sarcopenic older adults: A double-masked randomised controlled trial. Clinical Nutrition, 38(1), 159–164. https://doi.org/10.1016/j.clnu.2017.12.020

Ceglia, L., Niramitmahapanya, S., da Silva Morais, M., Rivas, D. A., Harris, S. S., Bischoff-Ferrari, H., Fielding, R. A., & Dawson-Hughes, B. (2013). A Randomized Study on the Effect of Vitamin D 3 Supplementation on Skeletal Muscle Morphology and Vitamin D Receptor Concentration in Older Women. The Journal of Clinical Endocrinology & Metabolism, 98(12), E1927–E1935. https://doi.org/10.1210/jc.2013-2820

Chandler, P. D., Wang, L., Zhang, X., Sesso, H. D., Moorthy, M. V., Obi, O., Lewis, J., Prince, R. L., Danik, J. S., Manson, J. E., LeBoff, M. S., & Song, Y. (2015). Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomised controlled trials. Nutrition Reviews, 73(9), 577–593. https://doi.org/10.1093/nutrit/nuv012

Chang, M. C., & Choo, Y. J. (2023). Effects of Whey Protein, Leucine, and Vitamin D Supplementation in Patients with Sarcopenia: A Systematic Review and Meta-Analysis. Nutrients, 15(3), 521. https://doi.org/10.3390/nu15030521

Chou, S. H., Murata, E. M., Yu, C., Danik, J., Kotler, G., Cook, N. R., Bubes, V., Mora, S., Chandler, P. D., Tobias, D. K., Copeland, T., Buring, J. E., Manson, J. E., & LeBoff, M. S. (2021). Effects of Vitamin D3 Supplementation on Body Composition in the VITamin D and OmegA-3 TriaL (VITAL). The Journal of Clinical Endocrinology & Metabolism, 106(5), 1377–1388. https://doi.org/10.1210/clinem/dgaa981

Cochet, C., Belloni, G., Buondonno, I., Chiara, F., & D’Amelio, P. (2023). The Role of Nutrition in the Treatment of Sarcopenia in Old Patients: From Restoration of Mitochondrial Activity to Improvement of Muscle Performance, a Systematic Review. Nutrients, 15(17), 3703. https://doi.org/10.3390/nu15173703

Dzik, K. P., & Kaczor, J. J. (2019). Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state. European Journal of Applied Physiology, 119(4), 825–839. https://doi.org/10.1007/s00421-019-04104-x

El Hajj, C., Fares, S., Chardigny, J. M., Boirie, Y., & Walrand, S. (2019). Vitamin D supplementation and muscle strength in pre-sarcopenic elderly Lebanese people: a randomised controlled trial. Archives of Osteoporosis, 14(1). https://doi.org/10.1007/s11657-018-0553-2

Fernando, R., Drescher, C., Nowotny, K., Grune, T., & Castro, J. P. (2019). Impaired proteostasis during skeletal muscle ageing. Free Radical Biology and Medicine, 132, 58–66. https://doi.org/10.1016/j.freeradbiomed.2018.08.037

Golzarand, M., Hollis, B. W., Mirmiran, P., Wagner, C. L., & Shab-Bidar, S. (2018). Vitamin D supplementation and body fat mass: a systematic review and meta-analysis. European Journal of Clinical Nutrition, 72(10), 1345–1357. https://doi.org/10.1038/s41430-018-0132-z

Hermawan, D., & Andoko. (2018). Analisis Kadar Vitamin D Dalam Darah pada Lanjut Usia di Lampung dan Faktor yang Mempengaruhinya. Jurnal Citra Keperawatan, 6(2).

Irawati, D., Ekawanti, A., & Josafat, A. (2020). Nutritional profile in Indonesian elderly subpopulation. Jurnal Kedokteran Dan Kesehatan Indonesia, 11(2), 121–129. https://doi.org/10.20885/JKKI.Vol11.Iss2.art4

Lin, C.-C., Shih, M.-H., Chen, C.-D., & Yeh, S.-L. (2021). Effects of adequate dietary protein with whey protein, leucine, and vitamin D supplementation on sarcopenia in older adults: An open-label, parallel-group study. Clinical Nutrition, 40(3), 1323–1329. https://doi.org/10.1016/j.clnu.2020.08.017

Oliai Araghi, S., van Dijk, S. C., Ham, A. C., Brouwer-Brolsma, E. M., Enneman, A. W., Sohl, E., Swart, K. M. A., van der Zwaluw, N. L., van Wijngaarden, J. P., Dhonukshe-Rutten, R. A. M., van Schoor, N. M., Zillikens, M. C., Lips, P., de Groot, L., Uitterlinden, A. G., & van der Velde, N. (2015). BMI and body fat mass are inversely associated with vitamin D levels in older individuals. The Journal of Nutrition, Health & Aging, 19(10), 980–985. https://doi.org/10.1007/s12603-015-0657-y

Pathak, K., Soares, M. J., Calton, E. K., Zhao, Y., & Hallett, J. (2014). Vitamin D supplementation and body weight status: a systematic review and meta‐analysis of randomised controlled trials. Obesity Reviews, 15(6), 528–537. https://doi.org/10.1111/obr.12162

Pinkas, J., Bojar, I., Gujski, M., Bartosińska, J., Owoc, A., & Raczkiewicz, D. (2017). Serum Lipid, Vitamin D Levels, and Obesity in Perimenopausal and Postmenopausal Women in Non-Manual Employment. Medical Science Monitor, 23, 5018–5026. https://doi.org/10.12659/MSM.906895

Ponti, F., Santoro, A., Mercatelli, D., Gasperini, C., Conte, M., Martucci, M., Sangiorgi, L., Franceschi, C., & Bazzocchi, A. (2020). Ageing and Imaging Assessment of Body Composition: From Fat to Facts. Frontiers in Endocrinology, 10. https://doi.org/10.3389/fendo.2019.00861

Rezuş, E., Burlui, A., Cardoneanu, A., Rezuş, C., Codreanu, C., Pârvu, M., Rusu Zota, G., & Tamba, B. I. (2020). Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age. International Journal of Molecular Sciences, 21(2), 592. https://doi.org/10.3390/ijms21020592

Rondanelli, M., Klersy, C., Terracol, G., Talluri, J., Maugeri, R., Guido, D., Faliva, M. A., Solerte, B. S., Fioravanti, M., Lukaski, H., & Perna, S. (2016). Whey protein, amino acids, and vitamin D supplementation with physical activity increases fat-free mass and strength, functionality, and quality of life and decreases inflammation in the sarcopenic elderly. The American Journal of Clinical Nutrition, 103(3), 830–840. https://doi.org/10.3945/ajcn.115.113357

Salles, J., Chanet, A., Guillet, C., Vaes, A. M., Brouwer-Brolsma, E. M., Rocher, C., Giraudet, C., Patrac, V., Meugnier, E., Montaurier, C., Denis, P., Le Bacquer, O., Blot, A., Jourdan, M., Luiking, Y., Furber, M., Van Dijk, M., Tardif, N., Yves Boirie, Y., & Walrand, S. (2022). Vitamin D status modulates mitochondrial oxidative capacities in skeletal muscle: role in sarcopenia. Communications Biology, 5(1), 1288. https://doi.org/10.1038/s42003-022-04246-3

Setiati, S., Laksmi, P. W., Aryana, I. G. P. S., Sunarti, S., Widajanti, N., Dwipa, L., Seto, E., Istanti, R., Ardian, L. J., & Chotimah, S. C. (2019). Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition. BMC Geriatrics, 19(1), 1–10. https://doi.org/10.1186/s12877-019-1198-8

Sun, D. S., Lee, H., Yim, H. W., Won, H. S., & Ko, Y. H. (2019). The impact of sarcopenia on health-related quality of life in older adults: Korean National Health and Nutrition Examination Survey. The Korean Journal of Internal Medicine, 34(4), 877–884. https://doi.org/10.3904/kjim.2017.182

Suryadinata, R. V., & Lorensia, A. (2020). Frekuensi Asupan Makanan, Pengetahuan Vitamin D dan Obesitas Pada Kelompok Usia Lanjut. Amerta Nutrition, 4(1), 43. https://doi.org/10.20473/amnt.v4i1.2020.43-48

Tomlinson, P. B., Joseph, C., & Angioi, M. (2015). Effects of vitamin D supplementation on upper and lower body muscle strength levels in healthy individuals. A systematic review with meta-analysis. Journal of Science and Medicine in Sport, 18(5), 575–580. https://doi.org/10.1016/j.jsams.2014.07.022

Vázquez-Lorente, H., Molina-López, J., Herrera-Quintana, L., Gamarra-Morales, Y., López-González, B., & Planells, E. (2020). Association between Body Fatness and Vitamin D3 Status in a Postmenopausal Population. Nutrients, 12(3), 667. https://doi.org/10.3390/nu12030667

Vitezova, A., Muka, T., Zillikens, M. C., Voortman, T., Uitterlinden, A. G., Hofman, A., Rivadeneira, F., Kiefte-de Jong, J. C., & Franco, O. H. (2017). Vitamin D and body composition in older people. Clinical Nutrition, 36(2), 585–592. https://doi.org/10.1016/j.clnu.2016.04.017

Widajanti, N., Ichwani, J., Dharmanta, R. S., Firdausi, H., Haryono, Y., Yulianti, E., Kandinata, S. G., Wulandari, M., Widyasari, R., Adyanita, V. A., Hapsanti, N. I., Wardana, D. M., Kristiana, T., Driyarkara, D., Wahyuda, H., Yunara, S., & Husna, K. (2020). Sarcopenia and Frailty Profile in the Elderly Community of Surabaya: A Descriptive Study. Acta Medica Indonesiana, 52(1), 5–13.

Zaidi, S. M. S., & Mutholaah, M. (2023). Sandwich generation in contemporary Indonesia: Determining responsibility in caring for elderly under Islamic law and positive law. Al-Manahij: Jurnal Kajian Hukum Islam, 167–182.

Zhao, Y., Zhao, W., Hao, Q., Ge, M., Zhang, Y., Hu, F., Lu, Y., Zhou, L., Liu, X., & Dong, B. (2021). Vitamin D status and obesity markers in older adults: results from West China Health and Aging Trends study. BMC Geriatrics, 21(1), 528. https://doi.org/10.1186/s12877-021-02449-7




DOI: http://dx.doi.org/10.30829/contagion.v6i1.19030

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