Partial Hydatidiform Mole with Subclinical Hyperthyroidism – A Case Report

R. Fuad Mustaqim, Aditiyono Aditiyono, Gatot N.A. Winarno, Dalri Muhammad Suhartomo

Abstract


Partial hydatidiform mole is a rare gestational trophoblastic disease marked by triploid karyotype, fetal abnormalities, and growth disorders, sometimes accompanied by subclinical hyperthyroidism. Diagnosis relies on β-hCG testing, ultrasound, and immunohistochemistry. Management, especially regarding chemotherapy, remains debated due to fertility concerns. This case report presents a rare instance of partial hydatidiform mole with subclinical hyperthyroidism, emphasizing key diagnostic and therapeutic considerations. A case report 22-year-old primigravida at 16 weeks presented with abortion imminens, placentomegaly, anemia, and massive bleeding. Evaluation confirmed a partial mole with subclinical hyperthyroidism. She was stabilized for hemorrhagic shock and IUFD, then underwent molar evacuation and caesarean hysterectomy. Although chemotherapy was initially planned, β-hCG levels normalized within 4 months without it, and follow-up showed no malignant transformation or recurrence. Low-risk partial hydatidiform mole can regress without chemotherapy, but comorbidities like subclinical hyperthyroidism require attention. At least 6 months of β-hCG monitoring is essential to confirm resolution and detect complications.

 

Keyword: Chemotherapy, Hyperthyroid Subclinical, Partial Hydatidiform Mole.

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References


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DOI: http://dx.doi.org/10.30829/contagion.v7i2.24775

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Contagion: Scientific Periodical Journal of Public Health and Coastal Health by Program Studi Ilmu Kesehatan Masyarakat is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.