Maternal Mortality in Cardiac Pregnancy: Ethical Conflicts in Patient Autonomy and Clinical Decision-Making
Abstract
Maternal mortality remains a significant concern in pregnancies complicated by heart disease, especially when patient preferences diverge from evidence-based clinical recommendations. These situations present complex clinical and ethical challenges for healthcare providers. This case report illustrates the interplay between patient autonomy, clinical decision-making, and outcomes in high-risk cardiac pregnancy. A 34-year-old multiparous woman with known cardiomegaly and valvular heart disease presented at 37–38 weeks’ gestation with worsening dyspnea, cardiac decompensation, and pulmonary hypertension. Despite medical advice recommending immediate delivery at a tertiary care center, she initially declined intervention. She later returned with severe preeclampsia and pulmonary hypertension. An emergency caesarean section was performed, but her condition deteriorated postoperatively, culminating in cardiac arrest and death. This case underscores the ethical tension between honoring patient autonomy, the right to make informed decisions, and the principle of beneficence, which obligates clinicians to act in the patient’s best interest. Decision-making was shaped by educational background, limited health literacy, cultural norms, family influence, and potential mistrust of the healthcare system, all of which may compromise truly informed consent. Addressing these barriers requires clear, accessible, and culturally attuned communication to ensure patients comprehend the risks and benefits. Integrating structured shared decision-making and early ethics consultation can help resolve conflicts, align care with patient values, and safeguard maternal and fetal outcomes. Ethical management demands a careful balance between respecting autonomy and preventing harm, while advocating for systemic reforms that address the social determinants of maternal health. Timely multidisciplinary care, culturally sensitive counseling, and structured shared decision-making are essential to harmonize patient autonomy with life-saving interventions in high-risk cardiac pregnancies, thereby reducing preventable maternal mortality.
Keyword: Ethical Dilemmas, Maternal Mortality, Cardiac Disease In Pregnancy.
Full Text:
PDFReferences
Aracil Moreno, I., Prieto-Arévalo, R., Ortega-Abad, V., Martín-Manzano, V., Pérez-Burrel, L., Fraile-López, A., Devesa-Cordero, C., Yllana-Pérez, F., Ortega, M. A., & De León-Luis, J. A. (2024). Maternal and Perinatal Outcomes in Pregnant Women with Heart Disease: A Case—Control Study. Journal of Clinical Medicine, 13(17), 1–12. https://doi.org/10.3390/jcm13175084
Chrvenak, F. A., & McCullough, L. B. (2019). Current Ethical Challenges in Obstetric and Gynecologic Practice, Research and Education. In For the FIGO Committee on Ethical and Professional Aspects of Human Reproduction and Women’s Health JAYPEE (First). Jaypee Brothers Medical Publishers (P) Ltd.
Coughlin, S. S., Vernon, M., & George, C. H. V. (2017). Health Literacy, Social Determinants of Health, and Disease Prevention and Control. Physiology & Behavior, 176(1), 100–106. https://doi.org/10.1177/0022146515594631.Marriage
Das, B. B., Aggarwal, V., & Deshpande, S. R. (2025). Navigating women with congenital heart disease during pregnancy: Management strategies and future directions. World Journal of Cardiology, 17(6), 1–31. https://doi.org/10.4330/wjc.v17.i6.106295
DeFilippis, E. M., Bhagra, C., Casale, J., Ging, P., Macera, F., & Lynn Punnoose. (2023). Cardio-Obstetrics and Heart Failure. JACC: Heart Failure; AMerican College of Cardiology Foundation, 11(no.9), 1165–1180. https://doi.org/10.1016/j.jchf.2023.07.009
Drigo, L., Makhado, L., Lebese, R. T., & Chueng, M. J. (2021). Influence of Cultural and Religious Practices on the Management of Pregnancy at Mbombela Municipality , South Africa : An Explorative Study Abstract : 130–135. https://doi.org/10.2174/1874434602115010130
Graham, E. L., Bove, R., Costello, K., Crayton, H., Jacobs, D. A., Shah, S., Sorrell, F., Stoll, S. S., & Houtchens, M. K. (2024). Practical Considerations for Managing Pregnancy in Patients With Multiple Sclerosis. Neurology Clinical Practice, 14(2). https://doi.org/10.1212/cpj.0000000000200253
Hameed, A. B., Haddock, A., Wolfe, D. S., Florio, K., Drummond, N., Allen, C., Taylor, I., Kendig, S., Presumey-Leblanc, G., & Greenwood, E. (2023). Alliance for innovation on maternal health Consensus Bundle on Cardiac Conditions in Obstetric Care. Obstet Gynecol, 141, 253–263. https://doi.org/0.1097/AOG.0000000000005048
Husey, H., Hussey, P., & Meng, M. L. (2017). Peripartum Consideration for Women with Cardiac Disease. Physiology & Behavior, 176(1), 100–106. https://doi.org/10.1177/0022146515594631.Marriage
Id, K. A. S., Kilby, C. J., Pehlivan, M., & Smith, B. (2021). Adequacy of measures of informed consent in medical practice : A systematic review. 1–17. https://doi.org/10.1371/journal.pone.0251485
Ilori, O., Kolawole, T. O., & Olaboye, J. A. (2024). Ethical dilemmas in healthcare management: A comprehensive review. International Medical Science Research Journal, 4(6), 703-725 Page 703. https://doi.org/10.51594/imsrj.v4i6.1251
Jennifer Lewey;, Lauren Andrade;, & Levine, L. D. (2021). Valvular Heart Disease in Pregnancy. HHS Public Access, 39(1), 151–161. https://doi.org/10.1016/j.ccl.2020.09.010
Kha, R., Melov, S. J., I., T. A., Kirby, A., & Choudhary, P. (2023). Predicting cardiac and pregnancy outcomes in women with adult congenital heart disease using the Anatomic and Physiological (AP) Classification System: How much does physiology matter. International Journal of Cardiology Congenital Heart Disease, 15. https://doi.org/10.1016/j.ijcchd.2023.100486
Lau, E. S., Aggarwal, N. R., Briller, J. E., Crousillat, D. R., Economy, K. E., Harrington, C. M., Lindley, K. J., & Malhamé, I. (2024). Recommendations for the Management of High-Risk Cardiac Delivery. JACC: Heart Failure; AMerican College of Cardiology Foundation, 3(No.4). https://doi.org/10.1016/j.jacadv.2024.100901
Montori, V. M., Ruissen, M. M., Hargraves, I. G., Brito, J. P., & Kunneman, M. (2023). Shared decision- making as a method of care. 28(4), 213–217.
Morton, A. (2021). Physiological Changes and Cardiovascular Investigations in Pregnancy. Heart, Lung and Circulation, 30, 6–15. https://doi.org/10.1016/j.hlc.2020.10.001
Nashat, H., Montanaro, C., Li, W., Kempny, A., Wort, S. J., Gatzoulis, M. A., & Babu-narayan, S. V. (2018). Atrial septal defects and pulmonary arterial hypertension. 10(4), 2953–2965. https://doi.org/10.21037/jtd.2018.08.92
Pietrzykowski, T., & Smilowska, K. (2021). The reality of informed consent: empirical studies on patient comprehension—systematic review. Trials, 22(1), 1–8. https://doi.org/10.1186/s13063-020-04969-w
Poungsuntorn, P., Suwanrath, C., Chainarong, N., Peeyananjarassri, K., Cheewatanakornkul, S., Duangpakdee, P., & Wongwaitaweewong, K. (2025). Prediction of cardiac events in pregnant women with cardiac diseases using modified WHO, CARPREG II, and ZAHARA risk assessments in southern Thailand. International Journal of Gynecology and Obstetrics, 1–2. https://doi.org/10.1002/ijgo.70196
Sahu, A. K., Harsha, M. M., & Rathoor, S. (2021). Cardiovascular Diseases in Pregnancy - A Brief Overview. Current Cardiology Reviews, 18(1), 77–88. https://doi.org/10.2174/1573403x17666210825103653
Sethi, D., & Kumar, N. (2020). Peripartum cardiomyopathy with preeclampsia in a parturient: A case report with literature review. Turkish Journal of Emergency Medicine, 20(4), 202–205. https://doi.org/10.4103/2452-2473.297467
Souza, R. D. D., Silversides, C. K., & Tomlinson, G. A. (2020). Assessing Cardiac Risk in Pregnant Women With Heart Disease : How Risk Scores Are Created and Their Role in Clinical Practice. Canadian Journal of Cardiology, 36(7), 1–5.
Teshale, M. Y., Bante, A., Belete, A. G., Crutzen, R., Spigt, M., & Stutterheim, S. E. (n.d.). Barriers and facilitators to maternal healthcare in East Africa : a systematic review and qualitative synthesis of perspectives from women , their families , healthcare providers , and key stakeholders.
Tringale, M., Stephen, G., Boylan, A.-M., & Heneghan, C. (2022). Integrating patient values and preferences in healthcare: a systematic review of qualitative evidence. BMJ Open, 12. https://doi.org/10.1136/ bmjopen-2022-067268
Türkmen, O., & Akar İnan, S. (2025). Navigating pregnancy with cardiovascular disease: Pathophysiology, risk stratification, and maternal–fetal outcomes. Turkish Journal of Medical Sciences, 55(1), 24–42. https://doi.org/10.55730/1300-0144.5940
Vandecasteele, R., Robijn, L., Willems, S., De Maesschalck, S., & Stevens, P. A. J. (2024). Barriers and facilitators to culturally sensitive care in general practice: a reflexive thematic analysis. BMC Primary Care, 25(1). https://doi.org/10.1186/s12875-024-02630-y
Varkey, B. (2021). Principles of Clinical Ethics and Their Application to Practice. Medical Principles and Practice, 30(1), 17–28. https://doi.org/10.1159/000509119
Vearrier, L., & Henderson, C. M. (2021). Utilitarian Principlism as a Framework for Crisis Healthcare Ethics. In HEC Forum (Vol. 33, Issues 1–2, pp. 45–60). https://doi.org/10.1007/s10730-020-09431-7
Whybrow, R., Webster, L. M., Seed, P. T., Sandall, J., & Chappell, L. C. (2022). The effectiveness of decision aids for pregnancy related decision-making in women with pre-pregnancy morbidity; systematic review and meta-analysis. BMC Pregnancy and Childbirth, 22:81. https://doi.org/10.1186/s12884-022-04402-x
Yang, C., Baker, P. N., Granger, J. P., Davidge, S. T., & Tong, C. (2023). Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring. Hypertension, 80(9), 1821–1833. https://doi.org/10.1161/HYPERTENSIONAHA.123.21061
Yevoo, L. L., Agyepong, I. A., Gerrits, T., & Dijk, H. Van. (2018). Mothers ’ reproductive and medical history misinformation practices as strategies against healthcare providers ’ domination and humiliation in maternal care decision- making interactions : an ethnographic study in Southern Ghana. 1–13.
Zolkefli, Y. (2024). Patient Refusal of Care : Balancing Patient Autonomy And Professional Ethical Short Commentary Patient Refusal of Care : Balancing Patient Autonomy and Professional Ethical Duties. August. https://doi.org/10.32598/JCCNC.10.3.63.1
DOI: http://dx.doi.org/10.30829/contagion.v7i2.24293
Refbacks
- There are currently no refbacks.
Copyright (c) 2025 Hanifan Nugraha, Muhammad Alamsyah Aziz, Dini Pusianawati

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
